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A disintegrin & metalloproteinase with thrombospondin type 1 motif 8; ADAMTS-8; ADAM-TS 8; ADAM-TS8; METH-2; METH-8 (ADAMTS8, METH2)
Function:
- has anti-angiogenic properties
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 2 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- highly expressed in adult & fetal lung,
- lower expression in brain, placenta, heart, stomach & fetal brain & kidney
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 890 aa
MW = 97 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
proline-rich region
SITE: 202-205
MOTIF: proline residue (SEVERAL)
Peptidase M12B {220-430}
MOTIF: Tyr phosphorylation site {Y255}
Ser phosphorylation site {S259}
cysteine residue {C342}
MODIFICATION: cysteine residue {C425}
N-glycosylation site {N345}
Zn+2-binding site
SITE: 364-364
glutamate residue {E365}
Zn+2-binding site
SITE: 368-368
Zn+2-binding site
SITE: 374-374
cysteine residue {C380}
MODIFICATION: cysteine residue {C409}
N-glycosylation site {N401}
cysteine residue {C409}
MODIFICATION: cysteine residue {C380}
cysteine residue {C425}
MODIFICATION: cysteine residue {C342}
disintegrin domain {439-526}
MOTIF: N-glycosylation site {N466}
N-glycosylation site {N491}
TSP1 module {527-582}
MOTIF: cysteine residue {C539}
MODIFICATION: cysteine residue {C576}
cysteine residue {C543}
MODIFICATION: cysteine residue {C581}
cysteine residue {C554}
MODIFICATION: cysteine residue {C566}
cysteine residue {C566}
MODIFICATION: cysteine residue {C554}
cysteine residue {C576}
MODIFICATION: cysteine residue {C539}
cysteine residue {C581}
MODIFICATION: cysteine residue {C543}
cysteine-rich region {584-690}
MOTIF: N-glycosylation site {N600}
Spacer {691-832}
TSP1 module {834-889}
Database Correlations
OMIM 605175
UniProt Q9UP79
PFAM correlations
Entrez Gene 11095
References
- UniProt :accession Q9UP79