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A disintegrin & metalloproteinase with thrombospondin type 1 motif 6; ADAMTS-6; ADAM-TS 6; ADAM-TS6; (ADAMTS6)
Function:
- interaction with the extracellular matrix
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 2 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- expressed at low levels in placenta
- barely detectable in a number of other tissues
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 860 aa
MW = 97 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
arginine-rich region {68-71}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N99}
N-glycosylation site {N172}
N-glycosylation site {N222}
N-glycosylation site {N234}
Peptidase M12B {250-452}
MOTIF: Zn+2-binding site
SITE: 403-403
glutamate residue {E404}
Zn+2-binding site
SITE: 407-407
Zn+2-binding site
SITE: 413-413
disintegrin domain {453-509}
TSP1 module {510-565}
MOTIF: cysteine residue {C522}
MODIFICATION: cysteine residue {C559}
cysteine residue {C526}
MODIFICATION: cysteine residue {C564}
cysteine residue {C537}
MODIFICATION: cysteine residue {C549}
cysteine residue {C549}
MODIFICATION: cysteine residue {C537}
cysteine residue {C559}
MODIFICATION: cysteine residue {C522}
cysteine residue {C564}
MODIFICATION: cysteine residue {C526}
cysteine-rich region {567-668}
MOTIF: glycine-rich region {662-665}
Spacer {669-795}
MOTIF: N-glycosylation site {N676}
TSP1 module {796-852}
MOTIF: N-glycosylation site {N843}
Database Correlations
OMIM 605008
UniProt Q9UKP5
PFAM correlations
Entrez Gene 11174
References
UniProt :accession Q9UKP5