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A disintegrin & metalloproteinase with thrombospondin type 1 motif 3; ADAMTS-3; ADAM-TS 3; ADAM-TS3; procollagen II amino propeptide-processing enzyme; procollagen II N-proteinase; PC II-NP (ADAMTS3, KIAA0366)
Function:
- cleaves the propeptides of collagen type 2 prior to fibril assembly.
- does not act on collagen type 1 or collagen type 3
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 4 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression: found in cartilage & skin
Note: has been referred to as ADAMTS4
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 1205 aa
MW = 136 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
N-glycosylation site {N83}
N-glycosylation site {N119}
N-glycosylation site {N242}
arginine-rich region {246-249}
MOTIF: arginine residue (SEVERAL)
Peptidase M12B {256-460}
MOTIF: N-glycosylation site {N345}
cysteine residue {C376}
MODIFICATION: cysteine residue {C455}
Zn+2-binding site
SITE: 398-398
glutamate residue {E399}
Zn+2-binding site
SITE: 402-402
Zn+2-binding site
SITE: 408-408
cysteine residue {C415}
MODIFICATION: cysteine residue {C441}
cysteine residue {C441}
MODIFICATION: cysteine residue {C415}
cysteine residue {C455}
MODIFICATION: cysteine residue {C376}
disintegrin domain {470-550}
MOTIF: N-glycosylation site {N475}
TSP1 module {551-606}
MOTIF: cysteine residue {C563}
MODIFICATION: cysteine residue {C600}
cysteine residue {C567}
MODIFICATION: cysteine residue {C605}
cysteine residue {C578}
MODIFICATION: cysteine residue {C590}
cysteine residue {C590}
MODIFICATION: cysteine residue {C578}
cysteine residue {C600}
MODIFICATION: cysteine residue {C563}
cysteine residue {C605}
MODIFICATION: cysteine residue {C567}
cysteine-rich region {608-712}
Spacer {713-844}
MOTIF: N-glycosylation site {N814}
TSP1 module {845-905}
TSP1 module {906-965}
MOTIF: N-glycosylation site {N942}
TSP1 module {966-1014}
MOTIF: cysteine residue {C978}
MODIFICATION: cysteine residue {C1010}
cysteine residue {C982}
MODIFICATION: cysteine residue {C1015}
cysteine residue {C993}
MODIFICATION: cysteine residue {C999}
cysteine residue {C999}
MODIFICATION: cysteine residue {C993}
cysteine residue {C1010}
MODIFICATION: cysteine residue {C978}
PLAC {1015-1054}
MOTIF: cysteine residue {C1015}
MODIFICATION: cysteine residue {C982}
Database Correlations
OMIM 605011
UniProt O15072
PFAM correlations
Entrez Gene 9508
Kegg hsa:9508
References
UniProt :accession O15072