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A disintegrin & metalloproteinase with thrombospondin type 1 motif 19; ADAMTS-19; ADAM-TS 19; ADAM-TS19 (ADAMTS19)
Function:
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 5 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- expressed in fetal lung
- not expressed in any adult tissues examined
Pathology:
- expression detected in an osteosarcoma cDNA library
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1207 aa
MW = 134 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
proline-rich region
SITE: 88-216
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N260}
Cysteine switch {292-299}
MOTIF: Zn+2-binding site
SITE: 294-294
Peptidase M12B {325-545}
MOTIF: cysteine residue {C460}
MODIFICATION: cysteine residue {C540}
Zn+2-binding site
SITE: 482-482
glutamate residue {E483}
Zn+2-binding site
SITE: 486-486
Zn+2-binding site
SITE: 492-492
cysteine residue {C499}
MODIFICATION: cysteine residue {C524}
cysteine residue {C524}
MODIFICATION: cysteine residue {C499}
cysteine residue {C540}
MODIFICATION: cysteine residue {C460}
disintegrin domain {546-633}
TSP1 module {634-686}
MOTIF: cysteine residue {C645}
MODIFICATION: cysteine residue {C680}
cysteine residue {C649}
MODIFICATION: cysteine residue {C685}
cysteine residue {C660}
MODIFICATION: cysteine residue {C670}
cysteine residue {C670}
MODIFICATION: cysteine residue {C660}
cysteine residue {C680}
MODIFICATION: cysteine residue {C645}
cysteine residue {C685}
MODIFICATION: cysteine residue {C649}
cysteine-rich region {687-790}
MOTIF: Ser phosphorylation site {S728}
Spacer {791-914}
MOTIF: N-glycosylation site {N797}
N-glycosylation site {N907}
TSP1 module {915-975}
MOTIF: N-glycosylation site {N949}
TSP1 module {976-1037}
MOTIF: cysteine residue {C988}
MODIFICATION: cysteine residue {C1031}
cysteine residue {C992}
MODIFICATION: cysteine residue {C1036}
cysteine residue {C1003}
MODIFICATION: cysteine residue {C1020}
N-glycosylation site {N1009}
cysteine residue {C1020}
MODIFICATION: cysteine residue {C1003}
cysteine residue {C1031}
MODIFICATION: cysteine residue {C988}
cysteine residue {C1036}
MODIFICATION: cysteine residue {C992}
TSP1 module {1039-1083}
TSP1 module {1087-1144}
PLAC {1160-1199}
Database Correlations
OMIM 607513
UniProt Q8TE59
PFAM correlations
Entrez Gene 171019
Kegg hsa:171019
References
UniProt :accession Q8TE59