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A disintegrin & metalloproteinase with thrombospondin type 1 motif 18; ADAMTS-18; ADAM-TS 18; ADAM-TS18 (ADAMTS18, ADAMTS21)
Function:
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon the activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 5 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in fetal lung, liver, & kidney & in adult brain, prostate, submaxillary gland, & endothelium
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 1221 aa
MW = 135 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-47}
N-glycosylation site {N151}
N-glycosylation site {N190}
Cysteine switch {252-259}
MOTIF: Zn+2-binding site
SITE: 254-254
Peptidase M12B {293-498}
MOTIF: N-glycosylation site {N313}
cysteine residue {C414}
MODIFICATION: cysteine residue {C493}
Zn+2-binding site
SITE: 436-436
glutamate residue {E437}
Zn+2-binding site
SITE: 440-440
Zn+2-binding site
SITE: 446-446
cysteine residue {C453}
MODIFICATION: cysteine residue {C477}
cysteine residue {C477}
MODIFICATION: cysteine residue {C453}
cysteine residue {C493}
MODIFICATION: cysteine residue {C414}
disintegrin domain {498-577}
TSP1 module {589-644}
MOTIF: cysteine residue {C601}
MODIFICATION: cysteine residue {C638}
cysteine residue {C605}
MODIFICATION: cysteine residue {C643}
cysteine residue {C616}
MODIFICATION: cysteine residue {C628}
cysteine residue {C628}
MODIFICATION: cysteine residue {C616}
cysteine residue {C638}
MODIFICATION: cysteine residue {C601}
cysteine residue {C643}
MODIFICATION: cysteine residue {C605}
cysteine-rich region {644-749}
MOTIF: N-glycosylation site {N745}
Spacer {750-876}
MOTIF: N-glycosylation site {N838}
N-glycosylation site {N909}
TSP1 module {931-990}
TSP1 module {991-1049}
TSP1 module {1052-1116}
TSP1 module {1123-1178}
PLAC {1184-1221}
Database Correlations
OMIM 607512
UniProt Q8TE60
PFAM correlations
Entrez Gene 170692
Kegg hsa:170692
References
UniProt :accession Q8TE60