Search
A disintegrin & metalloproteinase with thrombospondin type 1 motif 17; ADAMTS-17; ADAM-TS 17; ADAM-TS17 (ADAMTS17)
Function:
- precursor is cleaved by a furin endopeptidase
Structure:
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 5 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- expressed in fetal lung, in adult brain, prostate, & liver
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 1095 aa
MW = 121 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
arginine-rich region {60-120}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N167}
Cysteine switch {199-206}
MOTIF: Zn+2-binding site
SITE: 201-201
Peptidase M12B {232-452}
MOTIF: cysteine residue {C367}
MODIFICATION: cysteine residue {C447}
Zn+2-binding site
SITE: 389-389
glutamate residue {E390}
Zn+2-binding site
SITE: 393-393
Zn+2-binding site
SITE: 399-399
cysteine residue {C406}
MODIFICATION: cysteine residue {C431}
cysteine residue {C431}
MODIFICATION: cysteine residue {C406}
cysteine residue {C447}
MODIFICATION: cysteine residue {C367}
disintegrin domain {453-542}
MOTIF: N-glycosylation site {N483}
TSP1 module {543-598}
MOTIF: cysteine residue {C555}
MODIFICATION: cysteine residue {C592}
cysteine residue {C559}
MODIFICATION: cysteine residue {C597}
cysteine residue {C570}
MODIFICATION: cysteine residue {C582}
cysteine residue {C582}
MODIFICATION: cysteine residue {C570}
cysteine residue {C592}
MODIFICATION: cysteine residue {C555}
cysteine residue {C597}
MODIFICATION: cysteine residue {C559}
cysteine-rich region {599-701}
Spacer {702-779}
N-glycosylation site {N785}
N-glycosylation site {N790}
TSP1 module {800-860}
MOTIF: N-glycosylation site {N832}
N-glycosylation site {N839}
TSP1 module {861-922}
MOTIF: cysteine residue {C873}
MODIFICATION: cysteine residue {C916}
cysteine residue {C877}
MODIFICATION: cysteine residue {C921}
cysteine residue {C888}
MODIFICATION: cysteine residue {C905}
N-glycosylation site {N894}
cysteine residue {C905}
MODIFICATION: cysteine residue {C888}
cysteine residue {C916}
MODIFICATION: cysteine residue {C873}
cysteine residue {C921}
MODIFICATION: cysteine residue {C877}
TSP1 module {925-968}
TSP1 module {972-1029}
PLAC {1045-1084}
Database Correlations
OMIM 607511
UniProt Q8TE56
PFAM correlations
Entrez Gene 170691
Kegg hsa:170691
References
UniProt :accession Q8TE56