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A disintegrin & metalloproteinase with thrombospondin type 1 motif 16; ADAMTS-16; ADAM-TS 16; ADAM-TS16 (ADAMTS16, KIAA2029)
Function:
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & TSP type-1 domains are important for a tight interaction with the extracellular matrix
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 6 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in fetal lung & kidney & in adult prostate & ovary
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1224 aa
MW = 136 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
N-glycosylation site {N156}
Cysteine switch {247-254}
MOTIF: Zn+2-binding site
SITE: 249-249
Peptidase M12B {290-495}
MOTIF: N-glycosylation site {N310}
cysteine residue {C411}
MODIFICATION: cysteine residue {C490}
Zn+2-binding site
SITE: 433-433
glutamate residue {E434}
Zn+2-binding site
SITE: 437-437
Zn+2-binding site
SITE: 443-443
cysteine residue {C450}
MODIFICATION: cysteine residue {C474}
cysteine residue {C474}
MODIFICATION: cysteine residue {C450}
cysteine residue {C490}
MODIFICATION: cysteine residue {C411}
disintegrin domain {496-585}
TSP1 module {586-641}
MOTIF: cysteine residue {C598}
MODIFICATION: cysteine residue {C635}
cysteine residue {C602}
MODIFICATION: cysteine residue {C640}
cysteine residue {C613}
MODIFICATION: cysteine residue {C625}
cysteine residue {C625}
MODIFICATION: cysteine residue {C613}
cysteine residue {C635}
MODIFICATION: cysteine residue {C598}
cysteine residue {C640}
MODIFICATION: cysteine residue {C602}
cysteine-rich region {642-746}
MOTIF: N-glycosylation site {N741}
Spacer {747-873}
MOTIF: N-glycosylation site {N780}
N-glycosylation site {N835}
TSP1 module {874-922}
MOTIF: N-glycosylation site {N905}
TSP1 module {927-987}
MOTIF: N-glycosylation site {N935}
cysteine residue {C939}
MODIFICATION: cysteine residue {C981}
cysteine residue {C943}
MODIFICATION: cysteine residue {C986}
cysteine residue {C954}
MODIFICATION: cysteine residue {C970}
cysteine residue {C970}
MODIFICATION: cysteine residue {C954}
cysteine residue {C981}
MODIFICATION: cysteine residue {C939}
cysteine residue {C986}
MODIFICATION: cysteine residue {C943}
TSP1 module {988-1048}
TSP1 module {1051-1115}
MOTIF: Ser phosphorylation site {S1096}
TSP1 module {1127-1181}
PLAC {1186-1223}
Database Correlations
OMIM 607510
UniProt Q8TE57
PFAM correlations
Entrez Gene 170690
Kegg hsa:170690
References
UniProt :accession Q8TE57