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A disintegrin & metalloproteinase with thrombospondin type 1 motif 15; ADAMTS-15; ADAM-TS 15; ADAM-TS15 (ADAMTS15)
Function:
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 3 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- expressed in fetal liver & kidney
- not expressed in any adult tissues examined
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 950 aa
MW = 103 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
N-glycosylation site {N141}
Cysteine switch {172-179}
MOTIF: Zn+2-binding site
SITE: 174-174
Peptidase M12B {218-427}
MOTIF: cysteine residue {C339}
MODIFICATION: cysteine residue {C422}
Zn+2-binding site
SITE: 361-361
glutamate residue {E362}
Zn+2-binding site
SITE: 365-365
Zn+2-binding site
SITE: 371-371
cysteine residue {C377}
MODIFICATION: cysteine residue {C406}
cysteine residue {C406}
MODIFICATION: cysteine residue {C377}
cysteine residue {C422}
MODIFICATION: cysteine residue {C339}
disintegrin domain {428-515}
TSP1 module {516-571}
MOTIF: cysteine residue {C528}
MODIFICATION: cysteine residue {C565}
cysteine residue {C532}
MODIFICATION: cysteine residue {C570}
cysteine residue {C543}
MODIFICATION: cysteine residue {C555}
cysteine residue {C555}
MODIFICATION: cysteine residue {C543}
cysteine residue {C565}
MODIFICATION: cysteine residue {C528}
cysteine residue {C570}
MODIFICATION: cysteine residue {C532}
cysteine-rich region {572-700}
MOTIF: N-glycosylation site {N591}
N-glycosylation site {N623}
N-glycosylation site {N679}
Spacer {701-838}
TSP1 module {839-895}
TSP1 module {896-949}
Database Correlations
OMIM 607509
UniProt Q8TE58
PFAM correlations
Entrez Gene 170689
Kegg hsa:170689
References
UniProt :accession Q8TE58