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A disintegrin & metalloproteinase with thrombospondin type 1 motif 14; ADAMTS-14; ADAM-TS 14; ADAM-TS14 (ADAMTS14)
Function:
- aminoprocollagen type 1 processing activity in the absence of ADAMTS2
- seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity
- precursor is cleaved by a furin endopeptidase
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 4 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix
Alternative splicing: Named isoforms=4
- C produced by alternative splicing of isoform B
- D produced by alternative splicing of isoform A Alternative promoter:
- A,B: produced by alternative promoter usage
Expression:
- expressed in retina & at low levels in brain, lung & placenta
- high expression in fetal tissues
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 1223 aa
MW = 134 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N109}
Peptidase M12B {259-460}
MOTIF: cysteine residue {C376}
MODIFICATION: cysteine residue {C455}
Zn+2-binding site
SITE: 398-398
glutamate residue {E399}
Zn+2-binding site
SITE: 402-402
Zn+2-binding site
SITE: 408-408
cysteine residue {C415}
MODIFICATION: cysteine residue {C441}
cysteine residue {C441}
MODIFICATION: cysteine residue {C415}
cysteine residue {C455}
MODIFICATION: cysteine residue {C376}
disintegrin domain {461-551}
MOTIF: N-glycosylation site {N475}
TSP1 module {552-607}
MOTIF: cysteine residue {C564}
MODIFICATION: cysteine residue {C601}
cysteine residue {C568}
MODIFICATION: cysteine residue {C606}
cysteine residue {C579}
MODIFICATION: cysteine residue {C591}
cysteine residue {C591}
MODIFICATION: cysteine residue {C579}
cysteine residue {C601}
MODIFICATION: cysteine residue {C564}
cysteine residue {C606}
MODIFICATION: cysteine residue {C568}
cysteine-rich region {608-729}
Spacer {730-846}
TSP1 module {847-907}
MOTIF: arginine-rich region {875-878}
MOTIF: arginine residue (SEVERAL)
TSP1 module {908-967}
MOTIF: N-glycosylation site {N941}
TSP1 module {968-1022}
MOTIF: cysteine residue {C980}
MODIFICATION: cysteine residue {C1016}
cysteine residue {C984}
MODIFICATION: cysteine residue {C1021}
cysteine residue {C995}
MODIFICATION: cysteine residue {C1005}
cysteine residue {C1005}
MODIFICATION: cysteine residue {C995}
cysteine residue {C1016}
MODIFICATION: cysteine residue {C980}
cysteine residue {C1021}
MODIFICATION: cysteine residue {C984}
N-glycosylation site {N1027}
PLAC {1059-1097}
proline-rich region
SITE: 1100-1221
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 607506
UniProt Q8WXS8
PFAM correlations
Entrez Gene 140766
Kegg hsa:140766
References
UniProt :accession Q8WXS8