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A disintegrin & metalloproteinase with thrombospondin type 1 motif 10; ADAMTS-10; ADAM-TS 10; ADAM-TS10; (ADAMTS10)
Function:
- interaction with the extracellular matrix
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- spacer domain & the TSP type-1 domains are important for a tight interaction with the extracellular matrix
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 5 TSP type-1 domains
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression: widely expressed in adult tissues
Pathology:
- defects in ADAMTS10 are a cause of the autosomal recessive form of Weill-Marchesani syndrome
General
A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
glycoprotein
Properties
SIZE: entity length = 1103 aa
MW = 121 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
proline-rich region
SITE: 58-61
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N90}
N-glycosylation site {N222}
Peptidase M12B {239-457}
MOTIF: N-glycosylation site {N323}
cysteine residue {C370}
MODIFICATION: cysteine residue {C452}
Zn+2-binding site
SITE: 392-392
glutamate residue {E393}
Zn+2-binding site
SITE: 396-396
Zn+2-binding site
SITE: 402-402
cysteine residue {C409}
MODIFICATION: cysteine residue {C436}
cysteine residue {C436}
MODIFICATION: cysteine residue {C409}
cysteine residue {C452}
MODIFICATION: cysteine residue {C370}
disintegrin domain {460-546}
TSP1 module {547-602}
MOTIF: cysteine residue {C559}
MODIFICATION: cysteine residue {C596}
cysteine residue {C563}
MODIFICATION: cysteine residue {C601}
serine-rich region {568-571}
MOTIF: serine residue (SEVERAL)
cysteine residue {C574}
MODIFICATION: cysteine residue {C586}
cysteine residue {C586}
MODIFICATION: cysteine residue {C574}
cysteine residue {C596}
MODIFICATION: cysteine residue {C559}
cysteine residue {C601}
MODIFICATION: cysteine residue {C563}
cysteine-rich region {604-705}
Spacer {706-828}
MOTIF: N-glycosylation site {N740}
N-glycosylation site {N795}
TSP1 module {825-883}
TSP1 module {884-945}
MOTIF: N-glycosylation site {N892}
TSP1 module {947-1001}
TSP1 module {1003-1058}
PLAC {1065-1103}
Database Correlations
OMIM correlations
MORBIDMAP 608990
UniProt Q9H324
PFAM correlations
Entrez Gene 81794
Kegg hsa:81794
References
- UniProt :accession Q9H324
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS10