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A disintegrin & metalloproteinase domain-containing protein 7; ADAM 7; sperm maturation-related glycoprotein GP-83 (ADAM7, GP83)
Function:
- may play role in male reproduction including sperm maturation & gonadotrope function
- non catalytic metalloprotease-like protein (putative)
Structure:
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
Compartment: plasma membrane
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
glycoprotein
Properties
SIZE: entity length = 754 aa
MW = 86 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
N-glycosylation site {N84}
N-glycosylation site {N167}
N-glycosylation site {N174}
N-glycosylation site {N184}
Peptidase M12B {199-394}
MOTIF: cysteine residue {C310}
MODIFICATION: cysteine residue {C389}
cysteine residue {C350}
MODIFICATION: cysteine residue {C373}
cysteine residue {C352}
MODIFICATION: cysteine residue {C357}
cysteine residue {C357}
MODIFICATION: cysteine residue {C352}
cysteine residue {C373}
MODIFICATION: cysteine residue {C350}
cysteine residue {C389}
MODIFICATION: cysteine residue {C310}
disintegrin domain {402-488}
MOTIF: cysteine residue {C460}
MODIFICATION: cysteine residue {C480}
cysteine residue {C480}
MODIFICATION: cysteine residue {C460}
cysteine-rich region {489-668}
MOTIF: N-glycosylation site {N584}
N-glycosylation site {N668}
transmembrane domain {669-689}
Database Correlations
OMIM 607310
UniProt Q9H2U9
PFAM correlations
Entrez Gene 8756
Kegg hsa:8756
References
UniProt :accession Q9H2U9