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A disintegrin & metalloproteinase domain 29; cancer/testis antigen 73; CT73 (ADAM29)
Function:
- may be involved in spermatogenesis & fertilization
- seems to be a non catalytic metalloprotease-like protein
Structure:
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment: membrane
Alternative splicing: named isoforms=3; alpha, beta, gamma
Expression: expressed specifically in testes
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
glycoprotein
testis-specific protein
Properties
SIZE: MW = 93 kD
entity length = 820 aa
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: testis
MOTIF: metalloprotease domain {194-390}
MOTIF: N-glycosylation site {N217}
cysteine residue {C307}
MODIFICATION: cysteine residue {C384}
N-glycosylation site {N320}
cysteine residue {C347}
MODIFICATION: cysteine residue {C369}
N-glycosylation site {N368}
cysteine residue {C369}
MODIFICATION: cysteine residue {C347}
cysteine residue {C384}
MODIFICATION: cysteine residue {C307}
disintegrin domain {397-483}
MOTIF: N-glycosylation site {N428}
cysteine residue {C455}
MODIFICATION: cysteine residue {C468}
cysteine residue {C468}
MODIFICATION: cysteine residue {C455}
N-glycosylation site {N469}
cysteine-rich region {484-624}
MOTIF: N-glycosylation site {N538}
N-glycosylation site {N545}
N-glycosylation site {N558}
N-glycosylation site {N564}
EGF domain {625-654}
MOTIF: cysteine residue {C625}
MODIFICATION: cysteine residue {C636}
cysteine residue {C630}
MODIFICATION: cysteine residue {C642}
cysteine residue {C636}
MODIFICATION: cysteine residue {C625}
cysteine residue {C642}
MODIFICATION: cysteine residue {C630}
cysteine residue {C644}
MODIFICATION: cysteine residue {C653}
cysteine residue {C653}
MODIFICATION: cysteine residue {C644}
transmembrane domain {675-695}
Database Correlations
OMIM 604778
UniProt Q9UKF5
PFAM correlations
Entrez Gene 11086
Kegg hsa:11086
References
UniProt :accession Q9UKF5