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A disintegrin & metalloproteinase domain 23; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 3; MDC-3 (ADAM23, MDC3)
Function:
- may play a role in cell-cell & cell-matrix interactions
- non-catalytic metalloprotease-like protein
- ligand for integrin alpha-V/beta-3
Structure:
- conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment:
- cell membrane
- isoform gamma: secreted
Alternative splicing: named isoforms=3; alpha, beta, gamma
Expression:
- highly expressed in brain
- weakly expressed in heart
- in the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex & occipital pole
- highly expressed in the fetal brain
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
glycoprotein
phosphoprotein
Properties
SIZE: MW = 92 kD
entity length = 832 aa
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N76-N263} (3)
PEPTIDASE M12B {299-496}
MOTIF: cysteine residue {C408}
MODIFICATION: cysteine residue {C491}
cysteine residue {C450}
MODIFICATION: cysteine residue {C475}
cysteine residue {C452}
MODIFICATION: cysteine residue {C459}
cysteine residue {C459}
MODIFICATION: cysteine residue {C452}
cysteine residue {C475}
MODIFICATION: cysteine residue {C450}
cysteine residue {C491}
MODIFICATION: cysteine residue {C408}
DISINTEGRIN {502-588}
MOTIF: N-glycosylation site {N547}
N-glycosylation site {N548}
cysteine residue {C560}
MODIFICATION: cysteine residue {C580}
cysteine residue {C580}
MODIFICATION: cysteine residue {C560}
cysteine-rich region {589-611}
N-glycosylation site {N664}
EGF domain {732-769}
MOTIF: N-glycosylation site {N732}
cysteine residue {C736}
MODIFICATION: cysteine residue {C751}
cysteine residue {C745}
MODIFICATION: cysteine residue {C757}
cysteine residue {C751}
MODIFICATION: cysteine residue {C736}
cysteine residue {C757}
MODIFICATION: cysteine residue {C745}
cysteine residue {C759}
MODIFICATION: cysteine residue {C768}
cysteine residue {C768}
MODIFICATION: cysteine residue {C759}
transmembrane domain {793-813}
Database Correlations
OMIM 603710
UniProt O75077
PFAM correlations
Entrez Gene 8745
Kegg hsa:8745
References
- UniProt :accession O75077
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/ADAM23ID44041ch2q33.html