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A disintegrin & metalloproteinase domain 18; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein III; tMDC III (ADAM18, TMDC3, UNQ858/PRO1867)
Function:
- sperm surface membrane protein
- may be involved in spermatogenesis & fertilization
- non catalytic metalloprotease-like protein (putative)
- the prodomain & metalloprotease-like domain are cleaved during epididymal maturation of the spermatozoa
Structure:
- a tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor & thus could mediate sperm/egg binding
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: expressed specifically in testis
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
glycoprotein
testis-specific protein
Properties
SIZE: entity length = 739 aa
MW = 83 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-16}
N-glycosylation site {N36}
N-glycosylation site {N76}
N-glycosylation site {N122}
N-glycosylation site {N149}
N-glycosylation site {N156}
N-glycosylation site {N177}
Peptidase M12B {184-381}
MOTIF: cysteine residue {C293}
MODIFICATION: cysteine residue {C376}
N-glycosylation site {N294}
cysteine residue {C335}
MODIFICATION: cysteine residue {C360}
cysteine residue {C337}
MODIFICATION: cysteine residue {C342}
cysteine residue {C342}
MODIFICATION: cysteine residue {C337}
N-glycosylation site {N359}
cysteine residue {C360}
MODIFICATION: cysteine residue {C335}
cysteine residue {C376}
MODIFICATION: cysteine residue {C293}
disintegrin domain {390-479}
MOTIF: cysteine residue {C450}
MODIFICATION: cysteine residue {C471}
N-glycosylation site {N465}
cysteine residue {C471}
MODIFICATION: cysteine residue {C450}
cysteine-rich region {480-622}
MOTIF: N-glycosylation site {N561}
N-glycosylation site {N611}
EGF domain {620-654}
MOTIF: cysteine residue {C624}
MODIFICATION: cysteine residue {C636}
N-glycosylation site {N625}
cysteine residue {C630}
MODIFICATION: cysteine residue {C642}
cysteine residue {C636}
MODIFICATION: cysteine residue {C624}
cysteine residue {C642}
MODIFICATION: cysteine residue {C630}
cysteine residue {C644}
MODIFICATION: cysteine residue {C653}
cysteine residue {C653}
MODIFICATION: cysteine residue {C644}
transmembrane domain {688-708}
Database Correlations
UniProt Q9Y3Q7
PFAM correlations
Entrez Gene 8749
Kegg hsa:8749
References
UniProt :accession Q9Y3Q7