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tyrosine-protein kinase receptor UFO; AXL proto-oncogene protein (AXL, UFO)
Function:
- may function as a signal transducer between specific cell types of mesodermal origin
- heterodimer & heterotetramer with GAS6
- receptor tyrosine kinase
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily
- contains 2 fibronectin F3 modules
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment: membrane
Alternative splicing: named isoforms=2
Pathology:
- in case of filovirus infection, seems to function as a cell entry factor
- has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia
- originally identified as a tyrosine kinase encoded by a transforming gene from primary human myeloid leukemia cells
General
proto oncogene protein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 887 aa
MW = 97 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-18}
SKP1/GAS6 interaction {19-85}
immunoglobulin superfamily domain {20-121}
MOTIF: N-glycosylation site {N36}
cysteine residue {C49}
MODIFICATION: cysteine residue {C110}
Ser phosphorylation site {S93}
cysteine residue {C110}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {132-215}
MOTIF: N-glycosylation site {N150}
cysteine residue {C153}
MODIFICATION: cysteine residue {C198}
N-glycosylation site {N191}
cysteine residue {C198}
MODIFICATION: cysteine residue {C153}
fibronectin type III domain or F3 module {218-325}
fibronectin type III domain or F3 module {326-420}
MOTIF: N-glycosylation site {N332}
N-glycosylation site {N338}
N-glycosylation site {N394}
transmembrane domain {445-465}
kinase domain
SITE: 529-800
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 535-543
ATP-binding site
NAME: ATP-binding site
SITE: 560-560
aspartate residue {D665}
Tyr phosphorylation site {Y695}
Tyr phosphorylation site {Y696}
Ser phosphorylation site {S868}
Ser phosphorylation site {S877}
Database Correlations
OMIM 109135
UniProt P30530
PFAM correlations
ENZYME 2.7.10.1
References
- UniProt :accession P30530
- Varnum BC et al
Axl receptor tyrosine kinase stimulated by the vitamin K-
dependent protein encoded by growth-arrest-specific gene 6.
Nature 373:623 1995
PMID: 7854420