autoregulatory ribonucleoprotein complex (ARC)

Structure: subunits: IGF2BP1, PABPC1, CSDE1

Properties

SUBUNITS: insulin-like growth factor 2 mRNA-binding protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 2-75 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 81-156 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S181} Necessary for interaction with ELAVL4 and binding to TAU mRNA {187-570} MOTIF: KH domain SITE: 195-260 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 276-343 FOR-BINDING-OF: ribonucleic acid nuclear export {312-323} KH domain SITE: 405-470 FOR-BINDING-OF: ribonucleic acid domain {485-495} KH domain SITE: 487-553 FOR-BINDING-OF: ribonucleic acid polyadenylate-binding protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 11-89 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S96} RNP motif NAME: RNP motif SITE: 99-175 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y116} binding site SITE: 166-289 FOR-BINDING-OF: cold shock domain-containing protein E1 MOTIF: RNP motif NAME: RNP motif SITE: 191-268 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 294-370 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S315} Ser phosphorylation site {S342} Tyr phosphorylation site {Y364} alanine-rich region {495-501} MOTIF: alanine residue (SEVERAL) PABC {542-619} cold shock domain-containing protein E1 COMPARTMENT: cytoplasm MOTIF: cold shock NAME: cold shock SITE: 26-87 cold shock NAME: cold shock SITE: 136-179 cold shock NAME: cold shock SITE: 186-245 cold shock NAME: cold shock SITE: 297-337 cold shock NAME: cold shock SITE: 349-410 cold shock NAME: cold shock SITE: 447-507 cold shock NAME: cold shock SITE: 519-579 cold shock NAME: cold shock SITE: 610-670 cold shock NAME: cold shock SITE: 674-735

References

UniProt :accession Q9NZI8

Components

cold shock domain-containing protein E1 (UNR protein, N-ras upstream gene protein, CSDE1, D1S155E, KIAA0885, NRU, UNR) insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1, IMP-1, coding region determinant-binding protein, CRD-BP, VICKZ family member 1, IGF2BP1, CRDBP, VICKZ1) polyadenylate-binding protein 1; poly(A)-binding protein 1; PABP 1 (PABPC1, PAB1, PABP1, PABPC2)