autophagy protein 9-like 1; autophagy-related protein 9A; APG9-like 1; mATG9 (ATG9A, APG9L1)

Function: - role in autophagy - cycles between a juxta-nuclear trans-Golgi network compartment & late endosomes - nutrient starvation induces accumulation on autophagosomes - starvation-dependent trafficking requires ULK1, ATG13 & FAM48A - interacts with FAM48A Structure: belongs to the ATG9 family Compartment: - cytoplasmic vesicle, autophagosome membrane - multi-pass membrane protein (putative) - Golgi apparatus, trans-Golgi network membrane - late endosome membrane Alternative splicing: - named isoforms=3 - at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

autophagy protein (autophagy-related protein) glycoprotein phosphoprotein transmembrane 6 protein

Properties

SIZE: entity length = 839 aa MW = 94 kD COMPARTMENT: cytoplasm golgi MOTIF: cytoplasmic domain {1-66} MOTIF: Ser phosphorylation site {S14} Ser phosphorylation site {S18} transmembrane domain {67-87} exoplasmic loop {88-131} MOTIF: N-glycosylation site {N99} transmembrane domain {132-152} cytoplasmic loop {153-289} transmembrane domain {290-310} exoplasmic loop {311-371} transmembrane domain {372-392} cytoplasmic loop {393-400} transmembrane domain {401-421} exoplasmic loop {422-473} transmembrane domain {474-494} cytoplasmic domain {495-839} MOTIF: Ser phosphorylation site {S656} Ser phosphorylation site {S735} Ser phosphorylation site {S738} Ser phosphorylation site {S741} Ser phosphorylation site {S828}

Database Correlations

UniProt Q7Z3C6 Pfam PF04109 Entrez Gene 79065 Kegg hsa:79065

References

UniProt :accession Q7Z3C6