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autoimmune disease

A disease of autoimmunity. Pathology: - secretion of IL-17 by T-helper cells (Th17 cells) - increased serum levels of FCGBP Laboratory: - immunoassay for biomarkers of autoimmune arthritis [5] Management: - immunosuppression of various forms - investigational - in mice, digoxin suppresses production of IL-17 & onset of experimental autoimmune encephalitis [1] Comparative biology: - antigen-specific immunotherapy appears possible in mice [4] - type 1 diabetes, experimental autoimmune encephalomyelitis, &/or rheumatoid arthritis treated by creating tiny particles (nanomedicinea) coated by a disease-relevant peptide bound to MHC class II proteins - this caused generation of regulatory T cells that suppressed both autoantibody & cytotoxic T-cell attack on a specific target - no evidence of toxicity, including no opportunistic disease or malignancies

Interactions

disease interactions

Related

autoantibodies in rheumatologic disease autoimmune

Specific

acute hemorrhagic leukoencephalopathy alopecia areata ankylosing spondylitis, axial spondyloarthritis; Marie Strumpell disease; Bechterew's disease (AS) anti-glomerular basement membrane [GBM] disease anti-IgLON5 disease antiphospholipid syndrome (APS); Hughes syndrome autoimmune bullous disease (... pemphigus, bullous pemphigoid) autoimmune dementia autoimmune hemolytic anemia autoimmune lymphoproliferative syndrome (ALPS, Canale-Smith syndrome) autoimmune pancreatitis; lymphoplasmocytic sclerosing pancreatitis autoimmune polyglandular syndrome; autoimmune polyendocrine syndrome autoimmune sensorineural hearing loss autoimmune thyroid disease (autoimmune thyroiditis) autoimmune vasculitis Behcet syndrome cancer-associated retinopathy syndrome (CAR) celiac sprue (gluten-sensitive enteropathy) classic polyarteritis nodosa (PAN) dermatomyositis Evan's syndrome graft versus host disease (GVHD) granulomatosis with polyangiitis; Wegener's granulomatosis Graves disease (Basedow's disease, exothalmic goiter) Hashimoto's thyroiditis; chronic lymphocytic thyroiditis; struma lymphomatosa; lymphadenoid goiter; primary myxedema IgG4 disease immune effector cell-associated neurotoxicity syndrome (ICANS) immune or idiopathic thrombocytopenic purpura (ITP) immune-mediated necrotizing myopathy (IMNM) inflammatory bowel disease Kawasaki disease; mucocutaneous lymph node disease lymphocytic (autoimmune) hypophysitis multiple sclerosis (MS); includes clinically isolated syndrome myasthenia gravis myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) paraneoplastic syndrome pediatric acute-onset neuropsychiatric syndrome (PANS) pernicious anemia; autoimmune gastritis polymyalgia rheumatica (PMR) polymyositis primary biliary cirrhosis; primary biliary cholangitis psoriasis rheumatic fever rheumatoid arthritis (RA) sarcoidosis Schnitzler syndrome Sjogren's syndrome (autoimmune epitheliitis) Susac syndrome systemic lupus erythematosus systemic sclerosis Takayasu's arteritis; aortic arch syndrome; pulseless disease temporal arteritis; cranial arteritis; giant cell arteritis; Horton's disease Tn syndrome tropical spastic paraparesis

General

chronic immunologic disease

Database Correlations

OMIM 109100

References

  1. Huh JR et al Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORt activity. Nature 2011 Apr 28; 472:486 PMID: 21441909 - Solt LA et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 2011 Apr 28; 472:491 PMID: 21499262 - Jetten AM. A helping hand against autoimmunity. Nature 2011 Apr 28; 472:421 PMID: 21525918
  2. Castro C, Gourley M. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S238-47 PMID: 20061009
  3. van Assen S, Agmon-Levin N, Elkayam O et al EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011 Mar;70(3):414-22 PMID: 21131643
  4. Clemente-Casares X, Blanco J, Ambalavanan P et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 2016 Feb 25; 530:434. PMID: 26886799 - Wraith D. Antigen-specific immunotherapy. Nature 2016 Feb 25; 530:422 PMID: 26886797
  5. CPT :accession 81490
  6. Conti F, Rezai S, Valesini G. Vaccination and autoimmune rheumatic diseases. Autoimmun Rev 2008 Aug 14; 8:124 PMID: 18700175
  7. National Institute of Environmental Health Sciences Autoimmune Diseases https://www.niehs.nih.gov/health/topics/conditions/autoimmune/index.cfm