autocrine motility factor receptor (AMF receptor, gp78, AMFR)

Function: - specific receptor for the autocrine motility factor - ubiquitin ligase activity - can target both itself & other proteins, including CD3D & APOB for proteasomal degradation - component of complex required to couple retrotransloaction, ubiquitination, deglycosylation & proteasome-mediated degradation of misfolded proteins (NGLY1-SAKS1-AMFR-VCP-RAD23B complex, composed of NGLY1, SAKS1, AMFR, VCP & RAD23B) - role in ubiquitin-proteasome systems - interacts with UBE2G2/UBC7 through a region distinct from the RING finger Structure: - contains 1 CUE domain - contains 1 RING-type zinc finger Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=2 Pathology: - mediates tumor invasion & metastasis

General

receptor ring finger protein transmembrane 7 protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: MW = 73 kD entity length = 643 aa COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {82-102} transmembrane domain {122-142} transmembrane domain {145-165} transmembrane domain {186-206} transmembrane domain {215-235} transmembrane domain {276-296} RING-finger {341-379} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif transmembrane domain {429-449} CUE {456-498}

Database Correlations

OMIM 603243 UniProt Q9UKV5 PFAM correlations

References

UniProt :accession Q9UKV5