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aurothioglucose [gold] (Solganal)

Tradename: Solganal. [gold]. Rheumatoid arthritis: starting dose: 10 mg IM weekly. average dose: 50 mg IM monthly If no improvement after 1 g, reassess use of gold. Pharmacokinetics: 1) gold content is 50% 2) elimination 1/2 life varies with dose 3) 70% excreted in urine, 30% in feces Adverse effects: - rash, may be localized Toxicity: may be manifested by eosinophilia. Drug interactions: - may increase phenytoin levels Mechanism of action: 1) supresses of prevents arthritis & synovitis 2) taken up by macrophages resulting in inhibition of phagocytosis & perhaps lysosomal activity 3) decreases serum levels of rheumatoid factor & immunoglobulins 4) may decrease synovial inflammation & retard cartilage & bone destruction

Related

gold [Au]

General

disease-modifying antirheumatic agent (DMARD)

Properties

MISC-INFO: elimination route KIDNEY FECES 1/2life 3-27 DAYS protein-binding 99% pregnancy-category C safety in lactation -

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998.