serine/threonine protein kinase 12; Aurora kinase B; Aurora- & IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; serine/threonine protein kinase aurora-B (AURKB, AIK2, AIM1, ARK2, STK12)

Function: - may play role in regulating cleavage of polar spindle microtubules & regulating onset of cytokinesis during mitosis - component of the chromosomal passenger complex - phosphorylates Ser-10 & Ser-28 of histone H3 during mitosis - required for kinetochore localization of BUB1 & SGOL1 - interacts with INCENP - ubiquitinated by BCR E3 ubiquitin-protein ligase complexes - ubiquitination leads to removal from mitotic chromosomes & is required for cytokinesis - during anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone & mediates ubiquitination of AURKB - ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome - interacts with TACC1 - associates with RACGAP1 during M phase - interacts with CDCA1 & NDC80 - interacts with EVI5 - interacts with SEPT1 - interacts with PSMA3 Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily - contains 1 protein kinase domain Compartment: - nucleus, chromosome, centromere, spindle - cytoplasm, cytoskeleton - localizes on chromosome arms & inner centromeres from prophase through metaphase & then transferring to the spindle midzone & midbody from anaphase through cytokinesis - colocalized with gamma tubulin in the midbody Expression: - high level expression in the thymus - also expressed in the spleen, lung, testis, colon, placenta & fetal liver - expressed during S & G2/M phase & expression is up-regulated in cancer cells during M phase Pathology: - disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis

General

aurora kinase nuclear protein

Properties

SIZE: entity length = 344 aa MW = 39 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S7} Tyr phosphorylation site {Y12} Thr phosphorylation site {T16} Thr phosphorylation site {T35} Ser phosphorylation site {S45} Ser phosphorylation site {S61} Ser phosphorylation site {S62} Thr phosphorylation site {T64} kinase domain SITE: 77-327 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 83-91 Tyr phosphorylation site {Y92} ATP-binding site NAME: ATP-binding site SITE: 106-106 aspartate residue {D200} Ser phosphorylation site {S227} Thr phosphorylation site {T232} Thr phosphorylation site {T236} Ser phosphorylation site {S313} STATE: active state

Database Correlations

OMIM 604970 UniProt Q96GD4 Pfam PF00069 Entrez Gene 9212 KEGG correlations ENZYME 2.7.11.1

References

UniProt :accession Q96GD4