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aurora kinase
Function:
- role in phosphorylation of histones, promoting chromosome condensation;
- also interactd with chromosomal passenger proteins including inner centromere proteins & survivin
Pathology:
- overexpressed in some human cancers
Specific
Aurora-related kinase 3; Aurora kinase C; Aurora/IPL1-related kinase 3; ARK-3; serine/threonine protein kinase 13; Aurora/IPL1/Eg2 protein 2; serine/threonine protein kinase aurora-C (AURKC, AIE2, AIK3, ARK3, STK13)
serine/threonine protein kinase 12; Aurora kinase B; Aurora- & IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; serine/threonine protein kinase aurora-B (AURKB, AIK2, AIM1, ARK2, STK12)
serine/threonine protein kinase 6; Aurora kinase A; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; breast tumor-amplified kinase; serine/threonine protein kinase 15; serine/threonine protein kinase aurora-A (AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6)
General
serine/threonine kinase
Properties
STATE: active state
MOTIF: S/T phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
References
- Jallepalli & Lengauer.
Chromsosome segregation and cancer: cutting through the
mystery
Nature Reviews Cancer 1:109-117, 2001
PMID: 11905802