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AT-hook-containing transcription factor 1 (embryonic large molecule derived from yolk sac) (AHCTF1 ELYS TMBS62 MSTP108)
Function:
- probable transcription factor
- may play a specific role in hematopoietic tissues
- role in early development & survival of inner cells of the blastocyst (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 1 A.T hook DNA-binding domain
Compartment: nucleus matrix, cytoplasm (putative)
Alternative splicing: named isoforms=2
General
DNA-binding protein
Properties
SIZE: MW = 253 kD
entity length = 2275 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Necessary for cytoplasmic localization {10-990}
MOTIF: Ser phosphorylation site {S537}
Ser phosphorylation site {S1096}
nuclear translocation signal {1158-2275}
MOTIF: Ser phosphorylation site {S1241}
Ser phosphorylation site {S1292}
Ser phosphorylation site {S1304}
Mediates transcriptional activity {1455-1707}
Ser phosphorylation site {S1522}
Ser phosphorylation site {S1550}
A+T hook
SITE: 1955-1967
Ser phosphorylation site {S2005}
Ser phosphorylation site {S2221}
Ser phosphorylation site {S2231}
Ser phosphorylation site {S2235}
Database Correlations
UniProt Q8WYP5
Pfam PF02178
References
UniProt :accession Q8WYP5