AT-hook-containing transcription factor ( AKNA, KIAA1968)

Function: 1) transcription factor 2) specifically activates expression of CD40 receptor & its ligand CD40L/CD154, 2 cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development 3) binds to A/T-rich promoters Structure: contains 1 A.T hook DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=8 Expression: - predominantly expressed by lymphoid tissues - highly expressed in the spleen, lymph nodes & peripheral blood leukocytes - expressed at lower level in thymus - mainly expressed by germinal center B-lymphocytes, a stage in which receptor & ligand interactions are crucial for B-lymphocyte maturation - expressed by B- & T-lymphocytes, natural killer cells & CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells - weakly or not expressed in fetal liver & in adult bone marrow

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 155 kD entity length = 1439 aa COMPARTMENT: cell nucleus MOTIF: PEST {771-804} Ser phosphorylation site {S839} Ser phosphorylation site {S848} PEST {911-932} A+T hook SITE: 1115-1123

Database Correlations

OMIM 605729 UniProt Q7Z591

References

UniProt :accession Q7Z591