atypical chemokine receptor 4; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR (ACKR4, CCBP2, CCR11, CCRL1 ,VSHK1)

Function: - atypical chemokine receptor - controls chemokine levels & localization via high-affinity chemokine binding uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis - also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor - acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 & CCL25 - chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. - role in controlling the migration of immune & cancer cells that express chemokine receptors CCR7 & CCR9, by reducing the availability of CCL19, CCL21, & CCL25 through internalization - negatively regulates CXCR3-induced chemotaxis - regulates T-cell development in the thymus - the Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated - forms heteromers with CXCR3 - interacts with ARRB1 & ARRB2 Structure: - belongs to the G-protein coupled receptor 1 family atypical chemokine receptor subfamily Compartment: - early endosome. recycling endosome - cell membrane - predominantly localizes to endocytic vesicles, & upon stimulation by the ligand is internalized via caveolae - once internalized, the ligand dissociates from the receptor, & is targeted to degradation while the receptor is recycled back to the cell membrane Expression: - predominantly expressed in heart. - lower expression in lung, pancreas, spleen, colon, skeletal muscle & small intestine

General

atypical chemokine receptor; chemokine-scavenging receptor; chemokine decoy receptor CC chemokine receptor glycoprotein

Properties

SIZE: entity length = 350 aa MW = 40 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-42} MOTIF: N-glycosylation site {N6} N-glycosylation site {N19} transmembrane domain {43-63} cytoplasmic loop {64-87} transmembrane domain {88-108} exoplasmic loop {109-113} MOTIF: cysteine residue {C112} MODIFICATION: cysteine residue {C184} transmembrane domain {114-134} cytoplasmic loop {135-154} transmembrane domain {155-175} exoplasmic loop {176-201} MOTIF: cysteine residue {C184} MODIFICATION: cysteine residue {C112} transmembrane domain {202-222} cytoplasmic loop {223-240} transmembrane domain {241-261} exoplasmic loop {262-289} transmembrane domain {290-310} cytoplasmic domain {311-350}

References

UniProt :accession Q9NPB9

Databases & Figures

OMIM 606065 UniProt Q9NPB9 Pfam PF00001 Entrez Gene 51554 Kegg hsa:51554 CC ligand and receptor binding