atrial natriuretic peptide-converting enzyme; corin; heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; transmembrane protease serine 10; contains: atrial natriuretic peptide-converting enzyme, N-terminal propeptide; atrial natriuretic peptide-converting enzyme, activated protease fragment (CORIN, CRN, TMPRSS10)

Function: 1) converts Pro-ANP to ANP 2) cleaves Pro-ANP specifically between Arg-123 & Ser-124. Structure: - type 2 membrane protein Expression: highly expressed in heart

General

glycoprotein transmembrane serine protease

Properties

SIZE: MW = 117 kD entity length = 1042 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {46-66} N-glycosylation site {N80} N-glycosylation site {N104} FZ 1 {134-259} MOTIF: N-glycosylation site {N135} N-glycosylation site {N141} N-glycosylation site {N231} N-glycosylation site {N245} N-glycosylation site {N251} LDL-receptor class A {268-304} LDL-receptor class A {305-340} MOTIF: N-glycosylation site {N305} N-glycosylation site {N320} LDL-receptor class A {341-377} MOTIF: N-glycosylation site {N376} LDL-receptor class A {378-415} MOTIF: N-glycosylation site {N413} N-glycosylation site {N446} FZ 2 {450-573} MOTIF: N-glycosylation site {N451} N-glycosylation site {N469} N-glycosylation site {N567} LDL-receptor class A {579-614} LDL-receptor class A {615-653} MOTIF: N-glycosylation site {N651} LDL-receptor class A {654-690} SRCR {690-786} MOTIF: N-glycosylation site {N697} N-glycosylation site {N761} cysteine residue {C790} MODIFICATION: cysteine residue {C912} S1 domain {802-1035} MOTIF: cysteine residue {C828} MODIFICATION: cysteine residue {C844} histidine residue {H843} cysteine residue {C844} MODIFICATION: cysteine residue {C828} aspartate residue {D892} cysteine residue {C912} MODIFICATION: cysteine residue {C790} cysteine residue {C955} MODIFICATION: cysteine residue {C970} cysteine residue {C970} MODIFICATION: cysteine residue {C955} cysteine residue {C981} MODIFICATION: cysteine residue {C1010} serine residue {S985} cysteine residue {C1010} MODIFICATION: cysteine residue {C981} N-glycosylation site {N1022}

Database Correlations

OMIM 605236 UniProt Q9Y5Q5 PFAM correlations

References

UniProt :accession Q8IZH2