ATP-dependent RNA helicase DDX23; 100 kD U5 snRNP-specific protein; DEAD box protein 23; PRP28 homolog; U5-100kD (DDX23)

Function: 1) role in pre-mRNA splicing (putative) 2) component of U5 & U5.4/6 snRNP complexes 3) in vitro phosphorylated by CLK1 & U1 snRNP-associated protein kinase 4) identified in the spliceosome C complex 5) interacts with ERBB4 Structure: - belongs to the DEAD box helicase family, DDX23/PRP28 subfamily - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain Compartment: nucleus

General

helicase (DNA unwinding protein, DNA untwisting protein) phosphoprotein

Properties

SIZE: entity length = 820 aa MW = 96 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S14} arginine-rich region {20-122} MOTIF: arginine residue (SEVERAL) Thr phosphorylation site {T25} Ser phosphorylation site {S107} Ser phosphorylation site {S109} glutamate-rich region {128-240} MOTIF: glutamate residue (SEVERAL) Q motif {391-419} helicase NAME: helicase SITE: 422-627 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 435-442 DEAD/H box NAME: DEAD/H box SITE: 549-552 Helicase C-terminal {651-799}

Database Correlations

OMIM 612172 UniProt Q9BUQ8 PFAM correlations Entrez Gene 9416 Kegg hsa:9416 ENZYME 3.6.4.13

References

UniProt :accession Q9BUQ8