peroxisomal proliferator-activated receptor A-interacting complex 285 kD protein; ATP-dependent helicase PRIC285; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PDIP1; PPAR-gamma DBD-interacting protein 1 (PRIC285, KIAA1769, HELZ2)

Function: 1) helicase 2) transcriptional coactivator for nuclear receptors including - PPARA, PPARG, THRA, THRB, RXRA 3) interacts with PPARA, ESR1, THRB, RXRA, PPARG 4) component of PPAR alpha-interacting complex (PRIC) 5) interacts with the DNA-binding domain of PPARG Structure: - contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs - these motifs are not required for interaction with PPARG - belongs to the DNA2/NAM7 helicase family - contains 1 C2H2-type Zn⁺² finger Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood, placenta

General

C2H2 type zinc finger protein helicase (DNA unwinding protein, DNA untwisting protein) phosphoprotein receptor

Properties

SIZE: entity length = 2649 aa MW = 295 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 40-64 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S338} ATP-binding site NAME: ATP-binding site SITE: 544-551 DEAA box {667-670} alanine-rich region {968-1059} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S1006} LXXLL motif 1 {1075-1079} LXXLL motif 2 {1118-1122} LXXLL motif 3 {1173-1177} Tyr phosphorylation site {Y1507} LXXLL motif 4 {2012-2016} ATP-binding site NAME: ATP-binding site SITE: 2174-2181 LXXLL motif 5 {2229-2233}

Database Correlations

OMIM 611265 UniProt Q9BYK8 Pfam PF00773 Entrez Gene 85441 Kegg hsa:85441

References

UniProt :accession Q9BYK8