Search
ATP citrate lyase (citrate cleavage enzyme, ACLY)
Function:
- ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues
- role in de novo lipid synthesis.
- in nervous tissue it may be involved in the biosynthesis of acetylcholine
ADP + phosphate + acetyl-CoA + oxaloacetate
ATP + citrate + CoA
Structure:
- homotetramer
- N-terminal: succinate/malate CoA ligase beta subunit family
- C-terminal: succinate/malate CoA ligase alpha subunit family
Compartment: cytoplasm
Note:
- contrast to mitochondrial citrate synthase of citric acid cycle
Interactions
molecular events
Related
ATP citrate lyase gene
citrate synthase, mitochondrial; NADH cytochrome C reductase (CS)
Specific
citrate lyase beta subunit-like protein, mitochondrial; citrate lyase beta-like; beta-methylmalate synthase (CLYBL, CLB)
General
ketoacid-lyase
oligomerizing protein
phosphoprotein
Properties
CONFIGURATION: tetramer
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: His phosphorylation site
cofactor-binding site
COFACTOR-BOUND: coenzyme A
Database Correlations
OMIM 108728
UniProt P53396
PFAM correlations
Entrez Gene 47
Kegg hsa:47;
ENZYME 4.1.3.8
References
UniProt :accession P53396