Search
ATP-binding cassette, sub-family A, member 8 (ABCA8, KIAA0822)
Function:
- ATP-dependent lipophilic drug transporter
Kinetic parameters:
- KM=30.4 uM for estradiol-beta-glucuronide
- KM=0.1 uM for LTC4
- KM=10.3 uM for taurochlorate
- KM=5.0 uM for PAH
- KM=0.5 uM for estrone sulfate
Structure:
- belongs to the ABC transporter family. ABCA subfamily
- contains 2 ABC transporter domains
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- higher expression in heart, skeletal muscle & liver
General
ATP-binding cassette sub-family A (ABC transporter-A, ABCA)
glycoprotein
transmembrane 14 protein
Properties
SIZE: MW = 179 kD
entity length = 1581 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {30-50}
N-glycosylation site {N84}
transmembrane domain {220-240}
N-glycosylation site {N243}
transmembrane domain {268-288}
transmembrane domain {299-319}
transmembrane domain {327-347}
transmembrane domain {359-379}
transmembrane domain {397-417}
ABC transporter 1 {480-675}
MOTIF: N-glycosylation site {N484}
ATP-binding site
NAME: ATP-binding site
SITE: 516-523
N-glycosylation site {N555}
transmembrane domain {824-844}
N-glycosylation site {N908}
transmembrane domain {979-999}
transmembrane domain {1030-1050}
transmembrane domain {1066-1086}
transmembrane domain {1096-1116}
transmembrane domain {1121-1141}
transmembrane domain {1157-1177}
ABC transporter 2 {1245-1478}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1283-1290
Database Correlations
UniProt O94911
Pfam PF00005
Entrez Gene 10351
References
UniProt :accession O94911