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ATP-binding cassette sub-family G member 2; placenta-specific ATP-binding cassette transporter; breast cancer resistance protein; mitoxantrone resistance-associated protein; CDw338; CD338 (ABCG2, ABCP, BCRP, BCRP1, MXR)
Function:
- xenobiotic transporter
- may play a role in the exclusion of xenobiotics from the brain
- may be involved in brain-to-blood efflux
- appears to play a role in the multidrug resistance phenotype of several cancer cell lines
- when overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin & doxorubicin, display diminished intracellular accumulation of daunorubicin, & manifest an ATP- dependent increase in the efflux of rhodamine 123
- glycosylation-deficient ABCG2 is normally expressed & functional
Structure:
- monomer or homodimer
- disulfide-linked belongs to the ABC transporter family, ABCG (White) subfamily
- contains 1 ABC transporter domain
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in placenta
- low expression in small intestine, liver & colon
Pathology: up-regulated in brain tumors
Pharmacology:
- inhibited by danicopan (Voydeya)
General
ATP-binding cassette sub-family G (ABC transporter-G, ABG)
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 655 aa
MW = 72 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-395}
MOTIF: ABC transporter {37-286}
ATP-binding site
NAME: ATP-binding site
SITE: 80-87
transmembrane domain {396-416}
exoplasmic loop {417-428}
MOTIF: asparagine residue {418}
transmembrane domain {429-449}
cytoplasmic loop {450-477}
transmembrane domain {478-498}
exoplasmic loop {499-506}
transmembrane domain {507-527}
cytoplasmic loop {528-535}
transmembrane domain {536-556}
exoplasmic loop {557-630}
MOTIF: asparagine residue {557}
cysteine residue {C592}
MODIFICATION: cysteine residue {C608}
N-glycosylation site {N596}
cysteine residue {C603}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C608}
MODIFICATION: cysteine residue {C592}
transmembrane domain {631-651}
cytoplasmic domain {652-655}
Database Correlations
OMIM 603756
UniProt Q9UNQ0
PFAM correlations
Entrez Gene 9429
Kegg hsa:9429
References
- UniProt :accession Q9UNQ0
- SeattleSNPs
http://pga.gs.washington.edu/data/abcg2/