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ATP-binding cassette sub-family D member 2; adrenoleukodystrophy-related protein; hALDR; adrenoleukodystrophy-like 1 (ABCD2, ALD1, ALDL1, ALDR, ALDRP)
Function:
- probable transporter
- can form heterodimers with ABCD1/ALD & ABCD3/PMP70
- dimerization is necessary to form an active transporter
- interacts with PEX19
Structure:
- belongs to the ABC transporter family, ALD subfamily
- contains 1 ABC transmembrane type-1 domain
- contains 1 ABC transporter domain
Compartment: peroxisome membrane
Expression: predominantly expressed in brain & heart
Related
ABCD2 score
General
ATP-binding cassette sub-family D (ABC transporter-D, ABCD)
glycoprotein
Properties
SIZE: entity length = 740 aa
MW = 83 kD
COMPARTMENT: peroxisome
MOTIF: PEX19 interaction {1-218}
ABC transmembrane type-1 {107-399}
MOTIF: transmembrane domain {107-127}
transmembrane domain {144-164}
N-glycosylation site {N190}
N-glycosylation site {N227}
transmembrane domain {251-271}
transmembrane domain {351-371}
ABC transporter {478-704}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 511-518
Database Correlations
OMIM 601081
UniProt Q9UBJ2
PFAM correlations
Entrez Gene 225
Kegg hsa:225
References
UniProt :accession Q9UBJ2