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multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; MOAT-C; pABC11; SMRP (ABCC5, MRP5)
Function:
- acts as a multispecific organic anion pump which can transport nucleotide analogs
Structure:
- belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
- contains 2 ABC transmembrane type-1 domains
- contains 2 ABC transporter domains
Compartment: membrane
General
ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1437 aa
MW = 161 kD
COMPARTMENT: cellular membrane
MOTIF: ABC transmembrane type-1 1 {179-459}
MOTIF: transmembrane domain {179-199}
transmembrane domain {219-239}
transmembrane domain {296-316}
transmembrane domain {317-337}
transmembrane domain {400-420}
transmembrane domain {434-454}
N-glycosylation site {N494}
Ser phosphorylation site {S505}
Ser phosphorylation site {S509}
Thr phosphorylation site {T513}
ABC transporter 1 {562-783}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 595-602
transmembrane domain {608-628}
N-glycosylation site {N636}
N-glycosylation site {N684}
transmembrane domain {848-868}
ABC transmembrane type-1 2 {859-1155}
MOTIF: N-glycosylation site {N890}
N-glycosylation site {N897}
transmembrane domain {917-937}
transmembrane domain {997-1017}
transmembrane domain {1018-1038}
N-glycosylation site {N1044}
transmembrane domain {1104-1124}
transmembrane domain {1127-1147}
ABC transporter 2 {1193-1427}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1227-1234
N-glycosylation site {N1329}
N-glycosylation site {N1417}
Database Correlations
OMIM 605251
UniProt O15440
PFAM correlations
Entrez Gene 10057
References
UniProt :accession O15440