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multidrug resistance-associated protein 4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; multi-specific organic anion transporter B; MOAT-B (ABCC4 MRP4)
Function:
- may be an organic anion pump relevant to cellular detoxification
Structure:
- belongs to the ABC transporter family, conjugate
- transporter (TC 3.A.1.208) subfamily
- contains 2 ABC transmembrane type-1 domains
- contains 2 ABC transporter domains
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- high levels in prostate
- barely detectable in liver
General
ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1325 aa
MW = 150 kD
COMPARTMENT: cellular membrane
MOTIF: ABC transmembrane type-1 1 {92-377}
MOTIF: transmembrane domain {93-113}
transmembrane domain {136-156}
transmembrane domain {207-227}
transmembrane domain {228-248}
transmembrane domain {328-348}
transmembrane domain {351-371}
ABC transporter 1 {410-633}
MOTIF: transmembrane domain {440-460}
ATP-binding site
NAME: ATP-binding site
SITE: 445-452
Thr phosphorylation site {T646}
N-glycosylation site {N651}
N-glycosylation site {N690}
transmembrane domain {710-730}
ABC transmembrane type-1 2 {714-1005}
MOTIF: N-glycosylation site {N746}
N-glycosylation site {N754}
transmembrane domain {771-791}
N-glycosylation site {N792}
transmembrane domain {836-856}
transmembrane domain {858-878}
transmembrane domain {954-974}
transmembrane domain {977-997}
transmembrane domain {1038-1058}
ABC transporter 2 {1041-1274}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1075-1082
N-glycosylation site {N1176}
N-glycosylation site {N1309}
Database Correlations
OMIM 605250
UniProt O15439
PFAM correlations
Entrez Gene 10257
References
UniProt :accession O15439