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canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; multidrug resistance-associated protein 3; multi-specific organic anion transporter D; MOAT-D (ABCC3, CMOAT2, MLP2, MRP3)
Function:
- may act as an inducible transporter in the biliary & intestinal excretion of organic anions
- acts as an alternative route for the export of bile acids & glucuronides from cholestatic hepatocytes (putative)
Structure:
- belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
- contains 2 ABC transmembrane type-1 domains; residues 311594 & 971-1252
- contains 2 ABC transporter domains; residues 629-851 & 1323-1330
Compartment: membrane
Alternative splicing: named isoforms=4
additional isoforms seem to exist
some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense- mediated mRNA decay
Expression:
- mainly expressed in the liver
- also expressed in small intestine, colon, prostate, testis, brain & at a lower level in the kidney
General
ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
glycoprotein
phosphoprotein
transmembrane 17 protein
Properties
SIZE: entity length = 1527 aa
MW = 169 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N18}
transmembrane domain {33-53}
cytoplasmic loop {54-73}
transmembrane domain {74-94}
exoplasmic loop {95-99}
transmembrane domain {100-120}
cytoplasmic loop {121-132}
transmembrane domain {133-153}
exoplasmic loop {154-171}
transmembrane domain {172-192}
cytoplasmic loop {193-302}
transmembrane domain {303-323}
exoplasmic loop {324-349}
transmembrane domain {350-370}
cytoplasmic loop {371-426}
transmembrane domain {427-447}
exoplasmic loop {448-450}
transmembrane domain {451-471}
cytoplasmic loop {472-533}
transmembrane domain {534-554}
exoplasmic loop {555-576}
transmembrane domain {577-597}
cytoplasmic loop {598-963}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 661-668
Ser phosphorylation site {S908}
transmembrane domain {964-984}
exoplasmic loop {985-1021}
MOTIF: N-glycosylation site {N1006}
N-glycosylation site {N1007}
transmembrane domain {1022-1042}
cytoplasmic loop {1043-1085}
transmembrane domain {1086-1106}
exoplasmic loop {1107-1107}
transmembrane domain {1108-1128}
cytoplasmic loop {1129-1199}
transmembrane domain {1200-1220}
exoplasmic loop {1221-1222}
transmembrane domain {1223-1243}
cytoplasmic domain {1244-1527}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1323-1330
Database Correlations
OMIM 604323
UniProt O15438
PFAM correlations
Entrez Gene 8714
Kegg hsa:8714
References
UniProt :accession O15438