canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; multidrug resistance-associated protein 2; canalicular multidrug resistance protein (ABCC2, CMOAT, CMOAT1, CMRP, MRP2)

Function: - mediates hepatobiliary excretion of numerous organic anions - may function as a cellular cisplatin transporter Structure: - belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily - contains 2 ABC transmembrane type-1 domains; residues 322-605 & 979-1264 - contains 2 ABC transporter domains; residues 637-861 & 1300-1534 Compartment: membrane Expression: - found on the apical membrane of polarized cells in liver, kidney & intestine - the highest expression is found in liver Pathology: - defects in ABCC2 are the cause of Dubin-Johnson syndrome

General

ATP-binding cassette sub-family C (ABC transporter-C, ABCC) glycoprotein phosphoprotein transmembrane 17 protein

Properties

SIZE: entity length = 1545 aa MW = 174 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-27} MOTIF: N-glycosylation site {N7} N-glycosylation site {N12} transmembrane domain {28-48} cytoplasmic loop {49-68} transmembrane domain {69-89} exoplasmic loop {90-93} transmembrane domain {94-114} cytoplasmic loop {115-126} transmembrane domain {127-147} exoplasmic loop {148-165} transmembrane domain {166-186} cytoplasmic loop {187-313} MOTIF: Ser phosphorylation site {S283} transmembrane domain {314-334} exoplasmic loop {335-360} transmembrane domain {361-381} cytoplasmic loop {382-437} transmembrane domain {438-458} exoplasmic loop {459-461} transmembrane domain {462-482} cytoplasmic loop {483-544} transmembrane domain {545-565} exoplasmic loop {566-587} transmembrane domain {588-608} cytoplasmic loop {609-971} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 671-678 Ser phosphorylation site {S878} transmembrane domain {972-992} exoplasmic loop {993-1033} MOTIF: N-glycosylation site {N1011} transmembrane domain {1034-1054} cytoplasmic loop {1055-1097} transmembrane domain {1098-1118} exoplasmic loop {1119-1119} transmembrane domain {1120-1140} cytoplasmic loop {1141-1211} transmembrane domain {1212-1232} exoplasmic loop {1233-1234} transmembrane domain {1235-1255} cytoplasmic domain {1256-1545} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1334-1341

Database Correlations

OMIM correlations MORBIDMAP 601107 UniProt Q92887 PFAM correlations Entrez Gene 1244 Kegg hsa:1244