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ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2 (ABCA2, ABC2, KIAA1062)
Function:
- orphan transporter (natural substrate unknown)
- role in macrophage lipid metabolism (putative)
- role in neural development (putative)
Structure:
- belongs to the ABC transporter family, ABCA subfamily
- contains 2 ABC transporter domains
Compartment: membrane (putative)
Alternative splicing: named isoforms=2
General
ATP-binding cassette sub-family A (ABC transporter-A, ABCA)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 2435 aa
MW = 270 kD
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N14}
transmembrane domain {22-42}
transmembrane domain {54-74}
N-glycosylation site {N89}
N-glycosylation site {N168}
N-glycosylation site {N173}
N-glycosylation site {N305}
N-glycosylation site {N368}
N-glycosylation site {N379}
N-glycosylation site {N420}
N-glycosylation site {N432}
N-glycosylation site {N476}
N-glycosylation site {N484}
N-glycosylation site {N494}
N-glycosylation site {N530}
N-glycosylation site {N544}
N-glycosylation site {N590}
N-glycosylation site {N600}
N-glycosylation site {N628}
transmembrane domain {699-719}
transmembrane domain {750-770}
transmembrane domain {782-802}
transmembrane domain {813-833}
transmembrane domain {857-877}
transmembrane domain {893-913}
ABC transporter 1 {990-1221}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1024-1031
Ser phosphorylation site {S1327}
Ser phosphorylation site {S1331}
N-glycosylation site {N1408}
transmembrane domain {1456-1476}
N-glycosylation site {N1496}
N-glycosylation site {N1549}
N-glycosylation site {N1557}
N-glycosylation site {N1612}
N-glycosylation site {N1677}
N-glycosylation site {N1775}
transmembrane domain {1792-1812}
transmembrane domain {1841-1861}
transmembrane domain {1872-1892}
transmembrane domain {1905-1925}
transmembrane domain {1991-2011}
ABC transporter 2 {2050-2285}
MOTIF: N-glycosylation site {N2054}
ATP-binding site
NAME: ATP-binding site
SITE: 2087-2094
Thr phosphorylation site {T2412}
Database Correlations
OMIM 600047
UniProt Q9BZC7
Pfam PF00005
Entrez Gene 20
References
UniProt :accession Q9BZC7