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ATPase WRNIP1; Werner helicase-interacting protein 1 (WRNIP1, WHIP)
Function:
1) modulates initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis
2) intrinsic ATPase activity
3) sensor of DNA damage or of arrested replication forks
4) regulates the extent of DNA synthesis
5) interacts with POLD1, POLD2, POLD4
6) interacts with the N-terminal domain of WRN
7) interacts (via UBZ-type Zn+2 finger) with polyubiquitin
Structure:
- homooligomer, most likely an octamer
- belongs to the AAA ATPase family
- contains 1 UBZ-type Zn+2 finger Coompartment:
- nucleus (putative)
- colocalizes with WRN in granular structures in the nucleus
Alternative splicing: named isoforms=4
Expression: ubiquitously expressed
Related
Werner syndrome ATP-dependent helicase (WRN, RECQ3, RECQL2)
General
adenosine triphosphatase (ATPase)
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 665 aa
MW = 72 kD
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 17-40
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S65}
Ser phosphorylation site {S75}
Thr phosphorylation site {T85}
Ser phosphorylation site {S91}
Ser phosphorylation site {S92}
Thr phosphorylation site {T116}
Ser phosphorylation site {S151}
Ser phosphorylation site {S153}
ATP-binding site
NAME: ATP-binding site
SITE: 268-275
Tyr phosphorylation site {Y534}
Tyr phosphorylation site {Y562}
Database Correlations
OMIM 608196
UniProt Q96S55
PFAM correlations
Entrez Gene 56897
Kegg hsa:56897
References
UniProt :accession Q96S55