ATPase family AAA domain-containing protein 5 (chromosome fragility-associated gene 1 protein, ATAD5, C17orf41, FRAG1)

Function: - role in DNA damage response - involved in a RAD9A-related damage checkpoint - modulates RAD9A interaction with BCL2 & thereby induces DNA damage-induced apoptosis - interacts with RB1 predominantly in G1 phase via its LXCXE motif - interacts with RAD9A in growing cells - interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents - phosphorylated upon DNA damage, probably by ATM or ATR - ATR may stimulate the RAD9A dissociation Structure: belongs to the AAA ATPase family Compartment: nucleus (putative) Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 1844 aa MW = 208 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S621} Ser phosphorylation site {S663} Thr phosphorylation site {T664} ATP-binding site NAME: ATP-binding site SITE: 1132-1139 LXCXE {1428-1432} serine-rich region {1589-1599} MOTIF: serine residue (SEVERAL)

Database Correlations

UniProt Q96QE3 Pfam PF00004 Kegg hsa:7991

References

UniProt :accession Q96QE3