Search
atorvastatin/ezetimibe (Liptruzet)
Indications:
- hypercholesterolemia
- homozygous familial hypercholesterolemia
Contraindications:
- combination has not been shown to improve cardiovascular outcomes better than atorvastatin alone
Dosage:
- 10 mg ezetimibe, 10-80 mg atorvastatin
Adverse effects:
- changes in liver function tests
- muscle pain
- memory loss
- tendon problems
Mechanism of action:
- Liptruzet 10/20 lowers LDL cholesterol by 53% [1]
- atorvastatin inhibits HMG CoA reductase
- ezetimibe inhibits intestinal absorbtion of cholesterol
- see atorvastatin & ezetimibe
Interactions
drug interactions
General
pharmacologic combination
References
- Physician's First Watch, May 6, 2013
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- FDA Approves Merck's LIPTRUZET (ezetimibe and atorvastatin),
a New Product That Can Help Powerfully Lower LDL Cholesterol
http://www.mercknewsroom.com/press-release/fda-approves-mercks-liptruzet-ezetimibe-and-atorvastatin-new-product-can-help-powerful
- Patient Information LIPTRUZETTM (LIP-true-zett) (ezetimibe
and atorvastatin) Tablets.
http://www.merck.com/product/usa/pi_circulars/l/liptruzet/liptruzet_ppi.pdf
Components
atorvastatin (Lipitor)
ezetimibe (Zetia)