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atonal protein homolog 1 (helix-loop-helix protein hATH-1, ATOH1, ATH1)
Function:
1) activates E box-dependent transcription in association with TCF3/E47
2) activity antagonized by negative regulator of neurogenesis HES
3) role in differentiation of subsets of neural cells by activating E box-dependent transcription
4) efficient DNA binding requires dimerization with another bHLH protein
Structure:
- contains 1 basic helix-loop-helix (bHLH)
Compartment: nucleus
General
DNA-binding protein
Properties
SIZE: MW = 38 kD
entity length = 354 aa
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 29-38
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 160-171
helix-loop-helix
NAME: helix-loop-helix
SITE: 172-212
FOR-BINDING-VIA: helix-loop-helix
proline-rich region
SITE: 224-228
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 601461
UniProt Q92858
Pfam PF00010
References
UniProt :accession Q92858