ATF-like basic leucine zipper transcriptional factor B-ATF (SF-HT-activated gene 2, SFA-2, BATF)

Function: 1) negative regulator of AP-1 mediated transcription by binding to Jun proteins 2) Jun/B-ATF heterodimers bind DNA preferentially at the AP1-site (TRE) (consensus: 5'-TGA[CG]TCA-3') & weaker at the cAMP responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') but are transcriptionally inert 3) forms heterodimers with JUN, JUNB & JUND 4) interacts with IFI35 5) phosphorylated Structure: - belongs to the bZIP family - contains 1 bZIP domain Compartment: nucleus Expression: - expressed at highest levels in lung, & at lower levels in placenta, liver, kidney, spleen, & peripheral blood - strongly expressed in mature B- & T-lymphocytes Pathology: - detected in SW480 colorectal cancer cell line & in several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma

General

basic leucine zipper (bZIP) family protein DNA-binding protein

Properties

SIZE: MW = 14 kD entity length = 125 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 32-50 leucine zipper SITE: 54-75 FOR-BINDING-VIA: leucine zipper

Database Correlations

UniProt Q16520 Pfam PF00170

References

UniProt :accession Q16520