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ataxin-3-like protein (Machado-Joseph disease protein 1-like, ATXN3L, MJDL)
Function:
- may bind to histones & regulate transcription
- may act as a deubiquitinating enzyme
Structure:
- contains 1 Josephin domain
- contains 2 UIM repeats (ubiquitin-interacting motif repeats)
Compartment: nucleus
Note:
- may be product of a pseudogene, absence of intron in gene
Related
ataxin-3; Machado-Joseph disease protein 1; spinocerebellar ataxia type 3 protein (ATXN3, ATX3, MJD, MJD1, SCA3)
spinocerebellar ataxia type 3 (SCA-3); Machado-Joseph disease; Azorean disease
General
ataxin
hydrolase
nuclear protein
Properties
SIZE: MW = 41 kD
entity length = 355 aa
COMPARTMENT: cell nucleus
MOTIF: Josephin {1-180}
MOTIF: cysteine residue {C14}
histidine residue {H119}
asparagine residue {N134}
UIM {224-243}
UIM {244-258}
glutamine-rich region {291-300}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
UniProt Q9H3M9
PFAM correlations
References
UniProt :accession Q9H3M9