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ubiquilin-4; ataxin-1 ubiquitin-like-interacting protein A1U (UBQLN4, C1orf6, UBIN)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
- homodimer.
- binds SCA1
- binds signal sequences of proteins that are targeted to the endoplasmic reticulum (putative)
Structure:
- contains 1 UBA domain
- contains 1 ubiquitin-like domain
Compartment:
- nucleus, cytoplasm
- may associate with the endoplasmic reticulum
Expression:
- highly expressed in pancreas, kidney, skeletal muscle, heart & throughout the brain
- expressed at lower levels in placenta, lung & liver
Related
ubiquitin (UBCEP2, UBB, UBC)
General
nuclear protein
oligomerizing protein
phosphoprotein
ubiquilin
Properties
SIZE: entity length = 601 aa
MW = 64 kD
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ubiquitin-like {13-87}
Ser phosphorylation site {S318}
UBA domain {553-598}
Database Correlations
OMIM 605440
UniProt Q9NRR5
PFAM correlations
Entrez Gene 56893
Kegg hsa:56893
References
UniProt :accession Q9NRR5