ataxin-1-like; brother of ataxin-1 (ATXN1L, BOAT)

Function: - can supress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (putative) - interacts with CIC (putative) - interacts (via AXH domain) with NCOR2 - interacts with ATXN1 Structure: - homodimer - belongs to the ATXN1 family - contains 1 AXH domain Compartment: - nucleus - cell projection, dendrite - nuclear foci - colocalizes with NCOR2 & HDAC3 - distributed beyond the nucleus into the cell body & dendrites in Purkinje cells & in inferior olive cells Expression: expressed in cerebellum & cerebral cortex

Properties

SIZE: entity length = 689 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: NCOR2/ATXN1 interaction {20-197} MOTIF: self-association {20-197} proline-rich region SITE: 88-256 MOTIF: proline residue (SEVERAL) AXH {457-588}

References

UniProt :accession P0C7T5