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Astrotactin-1 (ASTN1 ASTN KIAA0289)
Function:
- neuronal adhesion molecule
- functions in postmitotic neuroblast migration along radial glial fibers
Structure:
- belongs to the astrotactin family
- contains 3 EGF-like domains
- contains 1 fibronectin F3 module
Compartment: membrane (potential)
Alternative splicing: named isoforms=2
Expression:
- neurons
General
cell adhesion protein
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1302 aa
MW = 145 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
Ser phosphorylation site {S54}
N-glycosylation site {N115}
transmembrane domain {154-174}
N-glycosylation site {N226}
N-glycosylation site {N382}
transmembrane domain {384-402}
N-glycosylation site {N453}
EGF domain {459-507}
MOTIF: cysteine residue {C463}
MODIFICATION: cysteine residue {C475}
cysteine residue {C471}
MODIFICATION: cysteine residue {C490}
cysteine residue {C475}
MODIFICATION: cysteine residue {C463}
cysteine residue {C490}
MODIFICATION: cysteine residue {C471}
cysteine residue {C492}
MODIFICATION: cysteine residue {C506}
cysteine residue {C506}
MODIFICATION: cysteine residue {C492}
EGF domain {608-652}
MOTIF: cysteine residue {C612}
MODIFICATION: cysteine residue {C625}
cysteine residue {C619}
MODIFICATION: cysteine residue {C636}
cysteine residue {C625}
MODIFICATION: cysteine residue {C612}
cysteine residue {C636}
MODIFICATION: cysteine residue {C619}
cysteine residue {C638}
MODIFICATION: cysteine residue {C651}
cysteine residue {C651}
MODIFICATION: cysteine residue {C638}
EGF domain {656-708}
MOTIF: cysteine residue {C660}
MODIFICATION: cysteine residue {C672}
cysteine residue {C668}
MODIFICATION: cysteine residue {C692}
cysteine residue {C672}
MODIFICATION: cysteine residue {C660}
cysteine residue {C692}
MODIFICATION: cysteine residue {C668}
cysteine residue {C694}
MODIFICATION: cysteine residue {C707}
cysteine residue {C707}
MODIFICATION: cysteine residue {C694}
N-glycosylation site {N729}
N-glycosylation site {N742}
N-glycosylation site {N804}
N-glycosylation site {N984}
fibronectin type III domain or F3 module {1030-1145}
MOTIF: Ser phosphorylation site {S1088}
Ser phosphorylation site {S1277}
Database Correlations
OMIM 600904
UniProt O14525
Entrez Gene 460
Kegg hsa:460
References
- Zheng C et al.
CNS gene encoding astrotactin, which supports neuronal
migration along glial fibers.
Science 272:417, 1996
PMID:8602532
- UniProt :accession O14525