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aspirin/oxycodone (Percodan)
5 mg oxycodone + 325 mg aspirin: DEA-controlled substance: class 2.
Contraindications:
pregnancy-category D
safety in lactation -
Dosage: 1 tabs PO every 6 hours.
Tablets: oxycodone HCl 4.5 mg, oxycodone terephthalate 0.38 mg & aspirin 325 mg
Pharmacokinetics: elimination: liver > kidney.
Adverse effects:
1) common (> 10%)
- weakness, tiredness, nausea/vomiting, hypotension, drowsiness, dizziness, heartburn, epigastric pain, dyspepsia
2) less common (1-10%)
- ureteral spasms, pain at site of injection, nervousness, headache, restlessness, anorexia, malaise, epigastric cramps, dry mouth, constipation, biliary spasm, decreased urination, confusion, dyspnea*, hemolytic anemia, rash, gastrointestinal ulceration, anaphylactic shock
3) uncommon (< 1%)
- paralytic ileus, depression, histamine release, hallucinations, paradoxical CNS stimulation, urticaria, increased intracranial pressure, physical & psychologic dependence, insomnia, nervousness, jitters, occult bleeding, prolongation of bleeding time, leukopenia, thrombocytopenia, hepatotoxicity, bronchospasm, iron deficiency anemia, renal insufficiency
* respiratory depression is dose & tolerance-related
Interactions
drug interactions
drug adverse effects of opiates
General
narcotic combination
Database Correlations
PUBCHEM cid=656791
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)
oxycodone (Roxicodone, OxyContin, OxyIR, OxyFast, Oxecta, Xtampza ER)