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aspartame

artificial sweetener Consumption: - should not be ingested by people with phenylketonuria - pregnant women advised to injest only moderate amounts - U.S. Food and Drug Administration has issued statements that aspartame does not pose a threat to the general population. - use of artificial sweeteners may facilitate reduction in sugar intake & thus in total calorie intake [2] - potential benefit in glycemic control [2] Adverse effects: - artificial sweeteners (especially aspartame & acesulfame-K) are associated with increased cancer risk (RR=1.15 for aspartame) [3] - WHO declares aspartame a possible carcinogen - link to hepatocellular carcinoma [5] - aspartame at doses < 15% of FDA maximum daily allowance can fuel anxiety [4] - also see artificial sweetener

General

artificial sweetener peptide

Database Correlations

PUBCHEM correlations

References

  1. Gorbitz CH Crystal and molecular structure of aspartame X HCl X 2H2O. Acta Chem Scand B. 1987 Feb;41(2):87-92. PMID: 3604519
  2. Gardner C et al Nonnutritive Sweeteners: Current Use and Health Perspectives : A Scientific Statement From the American Heart Association and the American Diabetes Association Circulation. published online July 9, 2012 PMID: 22777177 http://circ.ahajournals.org/content/early/2012/07/09/CIR.0b013e31825c42ee (corresponding NGC guideline withdrawn Dec 2017)
  3. Debras C, Chazelas E, Srour B et al Artificial sweeteners and cancer risk: Results from the NutriNet-Sante population-based cohort study. PLOS Medicine. 2022. Mar 24;19(3):e1003950 PMID: 35324894 PMCID: PMC8946744 Free PMC article https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950
  4. Brooks M Can a Common Artificial Sweetener Fuel Anxiety? Medscape. Dec 20, 2022 https://www.medscape.com/viewarticle/985861
  5. Worcester S WHO Declares Aspartame a Possible Carcinogen. Medscape. July 13, 2023 https://www.medscape.com/viewarticle/994362 - Riboli E Carcinogenicity of aspartame, methyleugenol, and isoeugenol. Lancet Oncology. 2023. July 13. PMID: 37454664 https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(23)00341-8/fulltext