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ASC-2/NCOA6 complex (MLL2/MLL3 complex, ASCOM complex)
Function:
1) coactivator complex of nuclear receptors
2) transcriptional coactivation
Structure:
- subunits include MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A & PAXIP1/PTIP.
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: histone-lysine N-methyltransferase 2D
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S27}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 226-276
EFFECTOR-BOUND: Zn+2
cysteine-rich region {229-326}
MOTIF: RING-finger {229-274}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 273-323
EFFECTOR-BOUND: Zn+2
RING-finger {276-321}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
proline-rich region
SITE: 374-1197
MOTIF: proline residue (SEVERAL)
15 X 5 AA repeats of S/P-P-P-E/P-E/A {439-668}
consensus repeat {442-446}
consensus repeat {460-464}
consensus repeat {469-473}
consensus repeat {496-500}
consensus repeat {504-508}
consensus repeat {521-525}
consensus repeat {555-559}
consensus repeat {564-568}
consensus repeat {573-577}
consensus repeat {582-586}
consensus repeat {609-613}
consensus repeat {618-622}
consensus repeat {627-631}
consensus repeat {645-649}
consensus repeat {663-667}
arginine-rich region {1290-1328}
MOTIF: arginine residue (SEVERAL)
glutamate-rich region {1351-1355}
MOTIF: glutamate residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1377-1430
EFFECTOR-BOUND: Zn+2
cysteine-rich region {1397-1510}
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1427-1477
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1504-1559
EFFECTOR-BOUND: Zn+2
MOTIF: RING-finger {1507-1557}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S1606}
Ser phosphorylation site {S1671}
proline-rich region
SITE: 2107-2626
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S2274}
Ser phosphorylation site {S2309}
Ser phosphorylation site {S2311}
proline-rich region
SITE: 2385-2392
MOTIF: proline residue (SEVERAL)
coiled coil {2669-2707}
MOTIF: LXXLL motif 1 {2686-2690}
alanine-rich region {2707-2713}
MOTIF: alanine residue (SEVERAL)
glutamine-rich region {2811-2822}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 2862-2978
MOTIF: proline residue (SEVERAL)
LXXLL motif 2 {3038-3042}
Ser phosphorylation site {S3130}
Thr phosphorylation site {T3197}
Ser phosphorylation site {S3199}
coiled coil {3249-3282}
glutamine-rich region {3261-4275}
MOTIF: glutamine residue (SEVERAL)
coiled coil {3562-3614}
coiled coil {3714-3750}
coiled coil {3897-3975}
Ser phosphorylation site {S4215}
LXXLL motif 3 {4222-4236}
proline-rich region
SITE: 4241-4360
MOTIF: proline residue (SEVERAL)
LXXLL motif 4 {4253-4257}
Ser phosphorylation site {S4359}
LXXLL motif 5 {4463-4467}
Ser phosphorylation site {S4738}
Ser phosphorylation site {S4822}
proline-rich region
SITE: 4909-4977
MOTIF: proline residue (SEVERAL)
LXXLL motif 6 {4990-4994}
RING-finger {5092-5137}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
FYR N-terminal {5175-5235}
FYR C-terminal {5236-5321}
SET domain {5397-5513}
MOTIF: binding site
SITE: 5451-5451
FOR-BINDING-OF: S-adenosylmethionine
S-adenosyl-L-methionine binding {5474-5475}
Zn+2-binding site
SITE: 5477-5477
post-SET domain {5521-5537}
MOTIF: Zn+2-binding site
SITE: 5525-5525
Zn+2-binding site
SITE: 5527-5527
Zn+2-binding site
SITE: 5532-5532
histone-lysine N-methyltransferase MLL3
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 34-46
coiled coil {92-112}
Zinc finger
NAME: Zinc finger
SITE: 341-391
EFFECTOR-BOUND: Zn+2
MOTIF: RING-finger {344-389}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger (3)
SITE: 388-520
EFFECTOR-BOUND: Zn+2
coiled coil {644-672}
Zinc finger
NAME: Zinc finger (3)
SITE: 957-1139
EFFECTOR-BOUND: Zn+2
coiled coil {1338-1366}
glutamine-rich region {1719-1796}
MOTIF: glutamine residue (SEVERAL)
coiled coil {1754-1787}
proline-rich region
SITE: 1834-2281
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 2412-2630
MOTIF: proline residue (SEVERAL)
glutamine-rich region {3012-3509}
MOTIF: glutamine residue (SEVERAL)
coiled coil {3054-3081}
coiled coil {3173-3272}
proline-rich region
SITE: 3277-3381
MOTIF: proline residue (SEVERAL)
coiled coil {3391-3433}
SET domain {4770-4891}
post-SET domain {4895-4911}
Set1/Ash2 histone methyltransferase complex subunit ASH2
COMPARTMENT: cell nucleus
MOTIF: Zn finger C4-type
SITE: 117-150
EFFECTOR-BOUND: Zn+2
B30.2/SPRY {360-583}
nuclear receptor coactivator 6
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 1-1310
FOR-BINDING-OF: nuclear receptor coactivator 1
MOTIF: binding site
SITE: 1-1057
FOR-BINDING-OF: CREB-binding protein
binding site
SITE: 1-928
FOR-BINDING-OF: TBP/GTF2A
glutamine-rich region {227-1041}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 372-377
MOTIF: proline residue (SEVERAL)
binding site
SITE: 773-927
FOR-BINDING-OF: trimethylguanosine synthase
Ser phosphorylation site {S884}
LXXLL motif 1 {887-891}
lysine-rich region {913-918}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T1321}
LXXLL motif 2 {1491-1495}
binding site
SITE: 1641-2063
FOR-BINDING-OF: EP300/CRSP3
retinoblastoma binding protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {22-63}
WD repeat {64-103}
WD repeat {148-188}
MOTIF: Ser phosphorylation site {S182}
Thr phosphorylation site {T193}
WD repeat {196-235}
WD repeat {249-291}
MOTIF: Thr phosphorylation site {T252}
WD repeat {293-331}
Ser phosphorylation site {S350}
Ser phosphorylation site {S388}
Ser phosphorylation site {S389}
Ser phosphorylation site {S497}
Dpy-30-like protein
COMPARTMENT: cell nucleus
WD repeat-containing protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {43-82}
WD repeat {85-126}
MOTIF: aspartate residue {107}
WD repeat {128-168}
MOTIF: phenylalanine residue {133}
WD repeat {169-208}
WD repeat {212-253}
WD repeat {256-296}
MOTIF: phenylalanine residue {263}
Ser phosphorylation site {S267}
WD repeat {299-333}
MOTIF: glutamate residue {322}
MEN1
lysine-specific demethylase 6A
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {9-17}
MOTIF: alanine residue (SEVERAL)
tetratricopeptide repeat {93-126}
tetratricopeptide repeat {130-163}
tetratricopeptide repeat {170-199}
tetratricopeptide repeat {205-238}
tetratricopeptide repeat {250-283}
tetratricopeptide repeat {284-317}
tetratricopeptide repeat {318-351}
tetratricopeptide repeat {352-385}
Ser phosphorylation site {S769}
Ser phosphorylation site {S818}
Ser phosphorylation site {S829}
Ser phosphorylation site {S1061}
JmjC {1095-1258}
MOTIF: Iron [Fe]-binding site
SITE: 1146-1146
Iron [Fe]-binding site
SITE: 1148-1148
PAX-interacting protein 1
COMPARTMENT: cell nucleus
MOTIF: BRCA1 C-terminal (BRCT) motif
SITE: 59-149
glutamate-rich region {155-182}
MOTIF: glutamate residue (SEVERAL)
glutamine-rich region {338-556}
MOTIF: glutamine residue (SEVERAL)
BRCA1 C-terminal (BRCT) motif
SITE: 567-660
MOTIF: nuclear translocation signal {634-651}
BRCA1 C-terminal (BRCT) motif
SITE: 667-755
BRCA1 C-terminal (BRCT) motif
SITE: 832-913
BRCA1 C-terminal (BRCT) motif
SITE: 934-975
tubulin alpha
MOTIF: GTP-binding site
SITE: N
GTP-binding site
SITE: E
domain
MOTIF: glycine residue (SEVERAL)
beta tubulin
MOTIF: mRNA autoregulation signal {N-TERMINUS}
MOTIF-SEQUENCE:
GTP-binding site
SITE: N
GTP-binding site
SITE: E
domain
MOTIF: glycine residue (SEVERAL)
References
UniProt :accession O15047
Components
beta tubulin
Dpy-30-like protein ()
histone-lysine N-methyltransferase 2D; lysine N-methyltransferase 2D; ALL1-related protein; myeloid/lymphoid or mixed-lineage leukemia protein 2 (KMT2D, ALR, MLL2, MLL4)
histone-lysine N-methyltransferase MLL3; homologous to ALR protein; lysine N-methyltransferase 2C; KMT2C; myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3, HALR, KIAA1506, KMT2C)
lysine-specific demethylase 6A; histone demethylase UTX; ubiquitously-transcribed TPR protein on the X chromosome; ubiquitously-transcribed X chromosome tetratricopeptide repeat protein (KDM6A, UTX)
nuclear receptor coactivator 6; amplified in breast cancer protein 3; cancer-amplified transcriptional coactivator ASC-2; activating signal cointegrator 2; ASC-2; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; nuclear receptor-activating protein, 250 kDa; nuclear receptor coactivator RAP250; NRC RAP250; thyroid hormone receptor-binding protein (NCOA6, AIB3, KIAA0181, RAP250, TRBP)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein, PAXIP1, PAXIP1L, PTIP, CAGF28)
retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)
tubulin alpha
WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)