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aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; class E basic helix-loop-helix protein 1; bHLHe1 (ARNT2, BHLHE1, KIAA0307)

see Ah receptor complex Function: - Ah receptor binds to DNA as heterodimer with ARNT - specifically recognizes the xenobiotic response element (XRE) - efficient DNA binding requires dimerization with another bHLH protein - heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein - interacts with TACC3 (putative) Structure: - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 PAC (PAS-associated C-terminal) domain - contains 2 PAS (PER-ARNT-SIM) domains Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: - expressed in brain, kidney, dorsal region of spinal cord & 1st branchial arch.

Interactions

molecular events

Related

aromatic hydrocarbon aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2) aryl hydrocarbon [Ah] receptor complex

General

basic helix loop helix (bHLH) family transcription factor

Properties

SIZE: entity length = 717 aa MW = 79 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 64-76 MOTIF: arginine-rich region {73-76} MOTIF: arginine residue (SEVERAL) helix-loop-helix NAME: helix-loop-helix SITE: 77-117 FOR-BINDING-VIA: helix-loop-helix PAS domain {134-209} PAS domain {323-393} PAC domain {398-441} glutamine-rich region {440-445} MOTIF: glutamine residue (SEVERAL) serine-rich region {552-555} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 606036 UniProt Q9HBZ2 PFAM correlations Entrez Gene 9915 Kegg hsa:9915

References

  1. UniProt :accession Q9HBZ2
  2. OMIM :accession 606036

Component-of

molecular complex